Endocrine Abstracts

Goitre incidence in school-aged children evaluated by the use of ultrasonography (US), apart from reflecting urine iodine concentration and percentage of households consuming iodized salt, is an essential indicator for assessing iodine intake in a given area. The position in which the US examination is being performed can also be an important problem in terms of its result interpretation. The aim of the study was to examine what is the difference between the thyroid volume mea...

Goiter prevalence (GP) and median UIC in population studies are both considered markers of iodine nutrition. Controversy exists which of them is more reliable.Aim: To assess correlation between UIC and thyroid volume in Polish schoolchildren.Material and methods: 9402 Polish schoolchildren (51.3% girls, 48.7% boys) aged 6–12 years were examined in 1999–2011 (‘Thyromobil’ action). 40.9% of children were born at l...

Recently, since the lives of patients with chronic renal failure have prolonged considerably, the importance of prevention and treatment of metabolic bone disease which inevitably develops in this group, has become better appreciated.The aim of this study was to evaluate the relation between bone mineral density (BMD) and specific markers of bone turnover in haemodialysis (HD) population.A cross-sectional study involving 40 HD pati...

Background: Clinically severe or recurrent subacute thyroiditis (SAT) frequently requires treatment with high cumulative doses of systemic steroids. Such therapy is associated with high risk of steroid-related complications. The DLISAT study aims to evaluate the efficacy and safety of intrathyroidal dexamethasone and lidocaine injections (DLI) in specific patient cohorts compared to standard oral steroid therapy. This report presents preliminary results after the initial six m...

Introduction: The functional interaction between the immune and endocrine systems remains intricate, and the relationships among various cell types and humoral mediators are not fully elucidated. Natural killer T (NKT) cells, being a heterogeneous T cell subpopulation, express markers specific for both natural killer (NK) cells (NK1.1, CD56) and T cells (TCR - T cell receptor). Thyroid-stimulating hormone (TSH) influences the immune system, and TSH receptors (TSHR) have been i...

Introduction: The time, degree and mode of pituitary function deterioration in patients with PROP1 mutation is not fully known and understood.Aim: To investigate the time and mode of pituitary function deterioration in the families/sporadic patients with PROP1 mutation during longitudinal observation.Methods: We performed a retrospective longitudinal (33 years, SD=12) analysis of 22 patients (11M/11W) with PROP1 mutation, including...

Background: Craniopharyngiomas are rare, relatively benign, slowly growing intracranial tumors originating in pituitary gland embryonic tissue. They may present at any age, with two peaks of occurrence in children and in older adults. Clinical symptoms are the result of mass effects. Treatment options include surgery, radio- and chemotherapy and unfortunately are connected with a high ratio of postoperative pituitary insufficiency.Aim: To present the lon...

Goiter frequency (GF) in schoolchildren and urinary iodine concentration (UIC) in an appropriately large population sample are iodine nutrition (IN) best indicators. GF in mildly iodine deficient areas should be assessed ultrasonographically, as palpation sensitivity in such cases is low.Aim: To assess thyroid volume reference values as IN marker in population with recently introduced obligatory iodine prophylaxis (OIP).Material an...

Poland was considered as a mild-to-moderate iodine deficiency area according to results of a nation-wide survey conducted in early 1990-ties. The obligatory iodine prophylaxis program based on iodization of house-hold salt (30 mg of iodide/1 kg of salt) was therefore introduced in 1997.The aim of the study was to assess the real impact of the Polish iodine prophylaxis model on thyroid volume in schoolchildren.Material and methods: ...

Introduction: Joubert Syndrome (JS) is a rare ciliopathy condition, presenting distinctive cerebellar and brain stem malformation called the “molar tooth sign” (MTS) on brain imaging. Patients suffer from neonatal breathing dysregulation, developmental delay, hypotonia, abnormal eye movements. Endocrine disorders are only rarely evaluated, to date only few reports highlight the importance of hormonal evaluation.Material...